Science › Background › Impact › 


Through the creation an integrative European research agenda on developmental origins of CLD, novel scientific knowledge will be generated on the

  • genomic and environmental determinants of CLDs and their interaction
  • underlying mechanisms how disease risks are established in early life
  • evolutionary conserved programs central to lung morphogenesis and CLD
  • role of developmental pathways in disease
  • molecular basis how disease risk transmitted across generations. 

The integrated analysis of these issues will enable developing concepts for preventative strategies and their preclinical validation on CLD for the future benefit of patients.
Indirect returns will be generated through the development of technologies such as methods for measuring lung function from birth onwards to give insight on normal lung ontogeny, and methods for lineage tracing of airway cells to track origin of pathological or beneficial cell types. 

Facebook Twitter Google Plus Google Bookmarks studiVZ Linkarena