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Objectives

The main objective is to promote basic and translational research on developmental origins of CLD to enable the development of preventative and novel therapeutic strategies. This will be achieved by focussing on the following scientific objectives which are reflected by the working groups:

  • The identification of early risk factors for adverse lung development
  • The identification of critical developmental periods when specific exposures are being operative
  • The identification of central cellular and molecular events during lung development and the elucidation of their relationship to CLD
  • The elucidation of the molecular basis and functional consequences of recapitulated developmental pathways in disease
  • The development and validation of transgenerational animal models to obtain insight into the underlying mechanisms of transmission of disease risks across generations and for testing preventative or early therapeutic interventions.
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