Science › Research › Working Group 3: Developmental Pathways & Lung Disease › 

Working Group 3: Developmental Pathways & Lung Disease

Head: Reinoud Gosens, Faculty of Mathematics and Natural Sciences, University of Groningen.

The goal of WG3 is to provide a translational and mechanistic link between the developmental mechanisms described in WG1 and 2 and the development of chronic lung disease in later life as studied in WG4. The impact of environmental exposures and genetic factors identified in WG1 on known (alveolar type II cells, airway smooth muscle cells, fibroblasts, airway epithelial cells, immune cells) and newly identified (from WG2) vulnerable cell populations will be assessed in vitro and in vivo, with emphasis on immunological and structural repair mechanisms, by research groups with complementary expertise and facilities. The objectives of these studies will be to increase our understanding of when and how developmental signalling pathways are reactivated during tissue injury and how these developmental signalling pathways help to coordinate immunological and structural repair responses. It is expected that these studies will identify mechanisms of disease, drug targets, diagnostic factors and prognostic factors for the susceptibility to chronic lung disease in later life.

 The main expected outcomes of WG3 will be:

  • Insight into the functional impact of environmental and genetic risk factors described in WG1 on the development of chronic lung disease in later life. The complimentary expertise and facilities of research groups within WG3 allows such studies in vitro (alveolar type II cells, airway smooth muscle cells, fibroblasts, airway epithelial cells) and in vivo (murine models for asthma, COPD and IPF) using pre-existing animal models, and cell and tissue banks from both foetal and adult human origin.
  • The identification of  triggers of aberrant reactivation of developmental pathways
  • The identification and validation of novel preclinical models to facilitate translational research in this area.
Share:
Facebook Twitter Google Plus Google Bookmarks studiVZ Linkarena Del.icio.us
EnglishDeutsch